Xeno-oestrogens and phyto-oestrogens are alternative ligands for the androgen receptor
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چکیده
منابع مشابه
Xeno-oestrogens and phyto-oestrogens are alternative ligands for the androgen receptor.
The androgen receptor (AR) plays a critical role in prostate cancer development and progression. This study aimed to use a computerized docking approach to examine the interactions between the human AR and phyto-oestrogens (genistein, daidzein, and flavone) and xeno-oestrogens (bisphenol A, 4-nonylphenol, dichlorodiphenyl trichloroethane [DDT], diethylstilbestrol [DES]). The predicted three-dim...
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The term phyto-oestrogen encompasses isoflavone compounds, such as genistein and daidzein, found predominantly in soya products and the lignans, such as matairesinol and secoisolariciresinol, found in many fruits, cereals and in flaxseed. There is evidence that they have potential health benefits in man particularly against hormone-dependent diseases such as breast and prostate cancers and oste...
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Phyto-oestrogens have emerged from their esoteric role in animal husbandry following the hypothesis that the human Western diet is relatively deficient in these substances compared with societies where large amounts of plant foods and legumes are eaten. Evidence is beginning to accrue that they may begin to offer protection against a wide range of human conditions, including breast, bowel, pros...
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In bovine oviduct cells 17beta-oestradiol can induce the synthesis of leukaemia inhibitory factor (LIF), a glycoprotein essential for embryo implantation. Therefore substances which are structurally similar to 17beta-oestradiol and possess oestrogenic activity may also modulate LIF synthesis and influence the reproductive process. We used primary cultures of bovine and human oviduct cells (epit...
متن کاملPhyto-oestrogens and the great soya debate
who follow natural diets and a holistic lifestyle appear to escape menopausal symptoms. Japanese women, for example, rarely experience hot flushes and other associated menopausal complaints (Aldercreutz et al 1992, Beyene 1986). On balance and considering the health risks, natural alternatives may be the best and safest option towards management of patients. However, in some instances HRT suppl...
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ژورنال
عنوان ژورنال: Asian Journal of Andrology
سال: 2010
ISSN: 1008-682X,1745-7262
DOI: 10.1038/aja.2010.14